Steroids and Traumatic Brain Injury: Time to Revisit?
نویسندگان
چکیده
Secondary insults such as brain edema are an important and relatively common event occurring after traumatic injury (TBI), leading to consequences raised intracranial pressure cerebral herniation. Further, posttraumatic inflammatory changes known significantly contribute neuronal dysfunction.
منابع مشابه
The Effects of Female Sex Steroids on Gastric Secretory Responses of Rat Following Traumatic Brain Injury
Objective(s) Gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. The female sex has more resistance to stress and the gastrointestinal lesions happen fewer than male sex. The purpose of this study was to evaluate the role of estradiol and progesterone on the gastric acid and pepsin levels following traumatic brain injury (TBI) induction. Materials and M...
متن کاملO 27: Traumatic Brain Injury and Inflammation
Traumatic brain injury (TBI) is a significant public health concern in our country, because of placing in top three most common causes of death and substantial direct and indirect costs to society. The incidence of TBI in our country is 1.7 times of international incidence. Traumatic brain injury induced by primary and secondary mechanisms that give rise to death and neurologic morbidity in pat...
متن کاملThe Role of Proinflammatory Cytokines in Mediation of Brain Antiedema Effect of Female Sex Steroids Following Traumatic Brain Injury
Background & Aims: Release of proinflammatory cytokines after traumatic brain injury (TBI) is a major cause of brain edema. Previous studies demonstrated that sex steroids decrease brain edema induced by TBI. In this study changes of brain cytokines after the administration of estrogen and progesterone 24 hours after TBI were evaluated. Materials and Methods: Female rats were divided into 7 gro...
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ژورنال
عنوان ژورنال: The Indian Journal of Neurotrauma
سال: 2023
ISSN: ['0973-0508']
DOI: https://doi.org/10.1055/s-0043-1769804